The filoviruses, ebola virus ebov and marburg virus marv, are among the deadliest viruses that cause disease in humans, with reported case fatality rates of up to 90% in some outbreaks. Currently, there are no approved vaccines or postexposure therapeutics. Treatment with antiserum and measures to reduce the bleeding are sometimes effective. The book provides a detailed description of the surgical pathology of thyroid diseases side by side with major advances in immunohistochemistry and molecular genetics that can be used in evaluating thyroid tumors and nonneoplastic diseases. Select up to three search categories and corresponding keywords using the fields to the right. Ebola viruses and marburg viruses include some of the most virulent and fatal pathogens known to. The first outbreak occurred simultaneously in 1967 in marburg, frankfurt, and belgrade with 31 human cases, 7 of which were. Marburg haemorrhagic fever was initially detected in 1967 after simultaneous outbreaks in marburg, from which the disease takes its name.
Marburg virus is the causative agent of marburg haemorrhagic fever mhf, a disease with a case fatality ratio of up to 88%. The epidemiology, pathogenesis, and clinical manifestations of ebola and marburg virus disease will bepresented here. We investigated the clinical and pathologic effects of experimental marv infection in egyptian rousettes through a serial euthanasia study and found clear evidence of. Marburg hemorrhagic fever centers for disease control. Fenner and whites medical virology, fifth edition provides an integrated view of related sciences, from cell biology, to medical epidemiology and human social behavior. Mandell, douglas, and bennetts principles and practice of. Part of the highly regarded diagnostic pathology series and written by danny a. Viruses free fulltext clinical, histopathologic, and. The explosion in clinical testing has been especially rapid in virology, where emerging viruses and growing numbers of viral infections are driving advances. Marburg hemorrhagic fever national center for emerging and zoonotic infectious diseases division of high consequence pathogens and pathology dhcpp marburg hemorrhagic fever marburg hf is a rare but severe hemorrhagic fever which affects both humans and nonhuman primates. Infectious diseases pathology branch, division of high consequence pathogens and pathology, centers for disease control and prevention, atlanta, ga, usa.
B, hepatocellular degeneration and necrosis with inflammation. Marburg virus disease an overview sciencedirect topics. Tissue and cellular tropism, pathology and pathogenesis of. Concise, focused chapters, supported by thousands of highquality images, make this second edition an excellent point. Gives a history of the appearance of the ebola and marburg viruses and details the characteristics of the ebola virus and techniques used to research it. Microbiologyvirologyimmunologybacteriologyparasitology. Virus biology of the most wellstudied member is described, with details of the viral genome and the protein machinery necessary to propagate viruses at the molecular and cellular level. Marburg virus brazil pdf ppt case reports symptoms. Marburg virus has the potential to be a serious public health threat, yet much more research is needed for us to understand the pathogenesis of the disease.
Etiology of human disease malnutrition infectious agents. This agent was called the marburg virus since most of the cases had occurred in marburg and the greater part of the laboratory work leading to the detection of the virus was performed in marburg. Marburg hemorrhagic fever, ebola hemorrhagic fever. It soon became obvious that the illness was a hitherto unknown infectious disease.
Brain cells from diseased patients accumulate a morphological feature known as lewy bodies which. Pathology of marburg virus disease marburg hemorrhagic. A, gross pathology of liver of marburg virus angola marvanginfected rhesus macaque, showing severe reticulation and discoloration. Greenmonkey disease marburg virus disease, a severe, distinctive, hemorrhagic illness with a high rate of mortality, is heralded early by severe sore throat, a maculopapular rash, and a red exanthem on the hard and soft palate. We describe the rapid identification, laboratory diagnosis, and case investigation of the third marburg virus. There are several types of viral disease, depending on the underlying virus. Encompassing everything from cold and flu viruses to sexually transmitted diseases, this important resource describes the cellular and tissue pathological changes attributable to infection in the. This protein mediates infection by binding to the viral envelope. Filovirus taxonomy is confusing, and for those who do not know the difference between marburg virus the virus marv, marburgvirus the genus, and marburgvirus marv and ravv, we recommend. Marburg virus marv causes marburg virus disease in humans and nonhuman primates, a form of viral hemorrhagic fever.
The epidemiology and pathogenesis of ebola virus disease will be presented here, including knowledge that emerged during and after the west african epidemic of ebola virus disease. In the late summer of 1967, several patients suffering from a severe disease were admitted to the department of medicine of the marburg university. No approved therapyis available for the treatment of these diseases, but progress has been made in new experimental approachesto postexposure prophylaxis andor treatment that are effective in laboratory primates 411. Marburg virus is considered to be a reemerging pathogen that poses a significant threat to human health. Free virology books download ebooks online textbooks. C, abundant immunopositive cells brown in liver of an untreated marvangpositive control animal at day 8 postinfection. Marburg virus is a hemorrhagic fever virus of the filoviridae family of viruses and a member of the species marburg marburgvirus, genus marburgvirus. Thirtyone people became ill, initially laboratory workers followed by several medical personnel and family members who had cared for them. Well go over some of the main types, including how they. For the marburg virus to infect the hosts cell an essential element is needed. This naturally occurring virus can cause a fulminating hemorrhagic disease. Pathology outlines recommended books by our editorial board.
The high virulence of ebov and marv is largely attributed to the ability of these viruses to interfere with the host immune response. For marburg and ebola that element is the niemannpick c1 npc1 membrane protein 1. Marburg virus is related to the ebola virus in that both viruses belong to the filovirus family. Scientists identify new mechanisms that offer protection. In humans and nonhuman primates, the clinical features and pathology of. The guide to clinical and diagnostic virology offers a digestible view of the breadth and depth of information related to clinical virology, providing a practical, working knowledge of the wide array of viruses that cause human disease. The perspective represented by this book, that of medical virology as an infectious disease science, is meant to provide a starting point, an anchor, for those who must relate the subject to clinical practice, public health. In september 2014, a single fatal case of marburg virus was identified in a healthcare worker in kampala, uganda. Marburg virus has caused a similar disease in a smaller number of outbreaks in. Pdf clinical, histopathologic, and immunohistochemical. The 9th edition continues the tradition of excellence with newly expanded chapters, increased global coverage, and regular updates to. Both viruses are represented by numerous isolates 1. Get the facts on the history, symptoms, and treatment of marburg virus disease, formerly known as marburg hemorrhagic fever.
Tissue and cellular tropism, pathology and pathogenesis of ebola and marburg viruses. Marburg disease the pathology of experimentally infected hamsters. Pathology and pathogenesis of human viral disease is a comprehensive reference that examines virus induced clinical disease of humans in the context of the responsible virus and its epidemiology. The clinical manifestations, diagnosis, treatment, and prevention of ebola virus disease are discussed elsewhere. Clinical aspects of marburg hemorrhagic fever medscape. Refer to the help section for more detailed instructions. Mvd is a viral hemorrhagic fever vhf, and the clinical symptoms are indistinguishable from ebola virus disease evd. Pathology and pathogenesis of human viral disease 1st. Marburg virus disease mvd formerly known as marburg haemorrhagic fever was first identified in 1967 during epidemics in marburg and frankfurt in germany and belgrade in the former yugoslavia from importation of infected monkeys from uganda.
Media in category marburg virus disease the following 4 files are in this category, out of 4 total. This information is used to build a widerscale virus host perspective with detail on the pathology and pathogenesis of ebola virus disease. Marburg haemorrhagic fever who regional office for africa. Marburg disease is a rare viral disease causing a hemorrhagic fever. Marburg virus marv is a member of the marburgvirus genus that contains two different viruses. Marburg virus was first recognized in 1967, when outbreaks of hemorrhagic fever occurred simultaneously in laboratories in marburg and frankfurt, germany and in belgrade, yugoslavia now serbia. Host specific and nonspecific defense mechanisms involved in resistance to and recovery from virus infections. It was discovered in 1967 in an epidemic in marburg, germany, and serbia, following exposure to african green monkeys, with 32 cases and seven deaths among laboratory workers and their families and caregivers. The diseases caused by herpes simplex types 1 and 2, cytomegalovirus, varicellazoster virus, epsteinbarr virus and other herpes types. For four decades, physicians and other healthcare providers have trusted mandell, douglas, and bennetts principles and practice of infectious diseases to provide expert guidance on the diagnosis and treatment of these complex disorders. Marburg haemorrhagic fever mhf is a viral haemorrhagic fever and a virus from the same family as the one that causes ebola haemorrhagic fever. These viruses are among the most virulent pathogens known to infect humans. Filovirus taxonomy is confusing, and for those who do not know the difference between marburg virus the virus marv, marburgvirus the genus, and marburgvirus marv and ravv, we recommend browsing. Marburg virus is a singlestranded rna virus genus marburgvirus, family filoviridae that is the etiologic agent of marburg hemorrhagic fever in humans and nonhuman primates mehedi et al.
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